Targeting energy metabolism in brain cancer with calorically restricted ketogenic diets
نویسندگان
چکیده
منابع مشابه
The calorically restricted ketogenic diet, an effective alternative therapy for malignant brain cancer
BACKGROUND Malignant brain cancer persists as a major disease of morbidity and mortality in adults and is the second leading cause of cancer death in children. Many current therapies for malignant brain tumors fail to provide long-term management because they ineffectively target tumor cells while negatively impacting the health and vitality of normal brain cells. In contrast to brain tumor cel...
متن کاملTargeting energy metabolism in brain cancer: review and hypothesis
Malignant brain tumors are a significant health problem in children and adults and are often unmanageable. As a metabolic disorder involving the dysregulation of glycolysis and respiration, malignant brain cancer is potentially manageable through changes in metabolic environment. A radically different approach to brain cancer management is proposed that combines metabolic control analysis with ...
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An important question about traditional caloric restriction (CR) experiments on laboratory mice is how food intake in the laboratory compares with that of wild mice in nature. Such knowledge would allow us to distinguish between two opposing views of the anti-aging effect of CR--whether CR represents, in laboratory animals, a return to a more normal level of food intake, compared with excess fo...
متن کاملImprovement in motor and exploratory behavior in Rett syndrome mice with restricted ketogenic and standard diets.
Rett syndrome (RTT) is a rare X-linked autistic-spectrum neurological disorder associated with impaired energy metabolism, seizure susceptibility, progressive social behavioral regression, and motor impairment primarily in young girls. The objective of this study was to examine the influence of restricted diets, including a ketogenic diet (KD) and a standard rodent chow diet (SD), on behavior i...
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BACKGROUND Based on the hypothesis that cancer cells may not be able to metabolize ketones as efficiently as normal brain cells, the ketogenic diet (KD) has been proposed as a complementary or alternative therapy for treatment of malignant gliomas. CASE PRESENTATION We report here our experience in treating two glioma patients with an IRB-approved energy-restricted ketogenic diet (ERKD) proto...
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ژورنال
عنوان ژورنال: Epilepsia
سال: 2008
ISSN: 0013-9580,1528-1167
DOI: 10.1111/j.1528-1167.2008.01853.x